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KMID : 0377519840090030445
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Chung-Ang Journal of Medicine
1984 Volume.9 No. 3 p.445 ~ p.459
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Radiologic and Histologic Studies of Pulmonary Interstitial Lesion Induced by Intrabronchial Instillation of Bleomycin in Rabbit
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Eun Tchoong-Kie
Park Soo-Soung
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Abstract
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The author has undertaken an experimental study inducing pulmonary interstitial lesion with bleomycin in rabbit. Bleomycin was instilled intrabronchially in single dose. 0.5㎎ and 1.0㎎ instillation of bleomycin in 0.05㏄ normal saline solution per 100g of body weight constitute bleomycin group A and B respectively, while 0.05㏄ instillation of normal saline constitutes a control group. Roentgenologic and histologic findings of pulmonary lesion from 2nd day to 56th day after intrabronchial instillation of bleomycin or saline solution were analyzed. The results were as follows: 1. Roentgenologic findings of bleomycin group included the increased density of variable patterns changing from alveolar density to mixed alveolar and interstitial density with lapse of time and heart shift to affected side in later stage, while those of control group were normal. 2. Histologic findings of bleomycin group were changed from inflammatory reaction to interstitial fibrosis with lapse of time. Adenomatosis, focal emphysema and bronchiolectasis appeared too. Minimal infiltration of macrophage in alveolar spaces was seen in control group. 3. Roentgenologic findings changing from alveolar density to mixed alveolar and interstitial density with lapse of time were correlated relatively well with histologic findings changing from the early inflammatory reaction in alveolar lumen and septa to the late interstitial fibrosis.
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